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Imipramine, sold under the brand names Tofranil and Tofranil PM, is the generic name of a prescription drug used to treat depression.
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Imipramine belongs to a group of drugs known as tricyclic antidepressants, or TCAs.
While TCAs have been on the market for decades, scientists are still unclear as to exactly how these drugs work.
However, they do know that they interfere with the body’s ability to draw norepinephrine and serotonin back up into nerve endings called synapses.
This increases the concentrations of these chemicals in the brain.
Originally manufactured by Sanofi Aventis, the Food and Drug Administration (FDA) first approved imipramine under the brand name Presamine in 1959.
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