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Olanzapine is a prescription medication used to treat schizophrenia. It is also used to treat bipolar disorder. Olanzapine belongs to a group of drugs called atypical antipsychotics, which work by altering the activity and levels of certain natural chemicals in the brain.
This medication comes in a tablet and an orally disintegrating tablet. Olanzapine is taken once a day, with or without food.
The orally disintegrating tablet is placed on the tongue, and the tablet will disintegrate quickly in your saliva so that you can easily swallow it with or without drinking liquid. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing.
Olanzapine is also available in a short-acting injection and in a long acting injection and is to be given directly into the muscle. 
Common side effects of olanzapine include lack of energy, dry mouth, increased appetite, somnolence, and tremor (shakes). 
Olanzapine is a prescription medicine used to treat schizophrenia and bipolar disorder. When olanzapine is combined with Prozac (fluoxetine) it is also used to treat:
This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
Olanzapine may be found in some form under the following brand names:
Olanzapine is part of the drug class:
Serious side effects may happen when you take olanzapine, including:
Common side effects of olanzapine include: lack of energy, dry mouth, increased appetite, sleepiness, tremor (shakes), having hard or infrequent stools, dizziness, changes in behavior, or restlessness.
Other common side effects in teenagers (13-17 years old) include: headache, stomach-area (abdominal) pain, pain in your arms or legs, or tiredness. Teenagers experienced greater increases in prolactin, liver enzymes, and sleepiness, as compared with adults.
Tell your doctor about any side effect that bothers you or that does not go away.
These are not all the possible side effects with olanzapine. For more information, ask your doctor or pharmacist.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:
This is not a complete list of olanzapine drug interactions. Ask your doctor or pharmacist for more information.
Olanzapine may cause serious side effects, including:
These serious side effects are described below.
1. Increased risk of death in elderly people who are confused, have memory loss and have lost touch with reality (dementia-related psychosis). Olanzapine is not approved for treating psychosis in elderly people with dementia.
2. High blood sugar (hyperglycemia). High blood sugar can happen if you have diabetes already or if you have never had diabetes. High blood sugar could lead to:
Your doctor should do tests to check your blood sugar before you start taking olanzapine and during treatment. In people who do not have diabetes, sometimes high blood sugar goes away when olanzapine is stopped. People with diabetes and some people who did not have diabetes before taking olanzapine need to take medicine for high blood sugar even after they stop taking olanzapine.
If you have diabetes, follow your doctor’s instructions about how often to check your blood sugar while taking olanzapine.
Call your doctor if you have any of these symptoms of high blood sugar (hyperglycemia) while taking olanzapine:
3. High fat levels in your blood (cholesterol and triglycerides). High fat levels may happen in people treated with olanzapine, especially in teenagers (13 to 17 years old). You may not have any symptoms, so your doctor should do blood tests to check your cholesterol and triglyceride levels before you start taking olanzapine and during treatment.
4. Weight gain. Weight gain is very common in people who take olanzapine. Teenagers (13 to 17 years old) are more likely to gain weight and to gain more weight than adults. Some people may gain a lot of weight while taking olanzapine, so you and your doctor should check your weight regularly. Talk to your doctor about ways to control weight gain, such as eating a healthy, balanced diet, and exercising.
Grapefruit and grapefruit juice may interact with olanzapine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.
Before starting olanzapine, tell your doctor if you have or had:
Tell your doctor if you are pregnant or breastfeeding
Tell your doctor if you exercise a lot or are in hot places often.
The symptoms of bipolar I disorder, treatment resistant depression, or schizophrenia may include thoughts of suicide or of hurting yourself or others. If you have these thoughts at any time, tell your doctor or go to an emergency room right away.
Tell your doctor about all the medicines that you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Olanzapine and some medicines may interact with each other and may not work as well, or cause possible serious side effects. Your doctor can tell you if it is safe to take olanzapine with your other medicines. Do not start or stop any medicine while taking olanzapine without talking to your doctor first.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if olanzapine will harm your unborn baby.
Tell your doctor if you are breastfeeding or plan to breastfeed. Olanzapine may be excreted in human breast milk. It may harm your nursing baby.
Olanzapine Intramuscular Injection :
Call your doctor if you do not think you are getting better or have any concerns about your condition while taking olanzapine.
Take olanzapine exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. Your doctor will determine the best dose for you, after weighing a number of factors including:
For the treatment of schizophrenia, the recommended starting dose of olanzapine in adults is 5 mg to 10 mg taken once daily. The maximum recommended daily dose is 20 mg. 
For the treatment of bipolar disorder, the recommended starting dose of olanzapine in adults is 10 mg to 15 mg taken once daily. The maximum recommended daily dose is 20 mg.
The recommended dose for short-acting intramuscular olanzapine for injection is 10 mg with a dose range of 2.5 mg to 10 mg.  A lower dose of 5 or 7.5 mg may be considered when clinical factors warrant.
The recommended dose range for long acting intramuscular olanzapine for injection is 150 mg to 300 mg administered every 2 weeks and with 405 mg administered every 4 weeks.
If you take too much olanzapine, call your local Poison Control Center or seek emergency medical attention right away.
Keep olanzapine and all medicines out of the reach of children.
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. Although the causes of death were varied, most of the deaths appeared to be either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. Olanzapine is not approved for the treatment of patients with dementia-related psychosis.
When using olanzapine and fluoxetine in combination, also refer to the Boxed Warning section of the package insert for Symbyax.

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